, Sjwall C The aim of this systematic literature review is to describe and analyse the . Injuries requiring medical treatment are considered to be "reportable incidents," and must be reported to the NJDOE within five working days of the occurrence. Beaton DE Visual Analog Scale Assessments Can Reliably Assess Disease Severity in SLE An acceptable reliability is indicated by values of intraclass correlation coefficient (ICC) or weighted >0.60 and a good reliability is >0.85 [20]. , Wallace DJ The authors wish to thank Sylvie Thuong for her invaluable assistance in the preparation of this manuscript. , Matos A , Farewell V CLOSED ANGLE/ ANGLE CLOSURE GLAUCOMA. , Siega-Riz AM Mahler M Parodis I Data regarding divergent validity are lacking for the PGA. Physician Global Assessment International Standardisation COnsensus in Elevation of erythrocyte sedimentation rate is associated with disease activity and damage accrual, The systemic lupus activity measure-revised, the Mexican systemic lupus erythematosus disease activity index (SLEDAI), and a modified SLEDAI-2K are adequate instruments to measure disease activity in systemic lupus erythematosus, Small changes in outpatients lupus activity are better detected by clinical instruments than by laboratory tests, Development and initial validation of the systemic lupus erythematosus disease activity index 2000 responder index 50, Sensitivity to change of 3 systemic lupus erythematosus disease activity indices: international validation, Systemic Lupus Erythematosus Disease Activity Index 2000 Responder Index 50: sensitivity to response at 6 and 12 months, Validation of the functional assessment of chronic illness therapy-fatigue scale in patients with moderately to severely active systemic lupus erythematosus, participating in a clinical trial, Psychological distress and changes in the activity of systemic lupus erythematosus, The rating scale preference measure as an evaluative measure in systemic lupus erythematosus, Comparison of the validity and sensitivity to change of 5 activity indices in systemic lupus erythematosus, Treatment of systemic lupus erythematosus with dehydroepiandrosterone: 50 patients treated up to 12 months, Soluble urokinase plasminogen activator receptor levels reflect organ damage in systemic lupus erythematosus, Epratuzumab for patients with moderate to severe flaring SLE: health-related quality of life outcomes and corticosteroid use in the randomized controlled ALLEVIATE trials and extension study SL0006, Measuring systemic lupus erythematosus activity during pregnancy: validation of the lupus activity index in pregnancy scale, Autoantibodies against albumin in patients with systemic lupus erythematosus, Association of depression with socioeconomic status, anticardiolipin antibodies, and organ damage in patients with systemic lupus erythematosus: results from the KORNET registry, Placebo-controlled randomized clinical trial of fish oils impact on fatigue, quality of life, and disease activity in systemic lupus erythematosus, Serum free light chains, interferon-alpha, and interleukins in systemic lupus erythematosus, Vitamin D levels in Chinese patients with systemic lupus erythematosus: relationship with disease activity, vascular risk factors and atherosclerosis, Systemic lupus erythematosus disease activity index 2000 responder index-50: a reliable index for measuring improvement in disease activity, Testosterone patches in the management of patients with mild/moderate systemic lupus erythematosus, Turkish LupusPRO: cross-cultural validation study for lupus, Cross-cultural validation of a disease-specific patient-reported outcome measure for lupus in Philippines, Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial, Sensitivity and specificity of plasma and urine complement split products as indicators of lupus disease activity, The TNF locus is altered in monocytes from patients with systemic lupus erythematosus, Effect of pregnancy on disease flares in patients with systemic lupus erythematosus, Frequency of lupus flare in pregnancy: the Hopkins Lupus Pregnancy Center experience, Morbidity of systemic lupus erythematosus: role of race and socioeconomic status, Classification and definition of major flares in SLE clinical trials, Efficacy and safety of epratuzumab in patients with moderate/severe active systemic lupus erythematosus: results from EMBLEM, a phase IIb, randomised, double-blind, placebo-controlled, multicentre study, COSMIN guideline for systematic reviews of patient-reported outcome measures, Validity and reliability in social science research, Understanding the minimum clinically important difference: a review of concepts and methods, Statistical significant change versus relevant or important change in (quasi) experimental design: some conceptual and methodological problems in estimating magnitude of intervention-related change in health services research, Minimum important difference between patients with rheumatoid arthritis: the patients perspective, Responsiveness and sensitivity to change of SLE disease activity measures, The Author(s) 2020. Physician Global Assessment (PGA) is a visual analogue score (VAS) that reflects the clinician's judgment of overall Systemic Lupus Erythematosus (SLE) disease activity. Using the Physician Global Assessment in a clinical setting to - PubMed The search strategy for SSc-related publications identified 75 citations . Changes in the PGA correlated with changes of other disease activity indices (SLEDAI, SLAM, LAI, patient global assessment), laboratory exams (ESR), patient-reported outcomes (Lupus Impact Tracker) [23, 50, 58, 77, 78, 81, 83] and response to treatment [4]. Medizinische Universitt Graz Austria/sterreich - Forschungsportal , Jnsen A , Ko T The PGA intraRR was assessed in three studies [10, 68, 94] and ranged from 0.55 [68] to 0.88 [10]. , Wallace DJ Construct validity was demonstrated by a good correlation (r 0.50) between the PGA with the SLEDAI (12 studies), SLAM (4 studies), LAI, BILAG and ECLAM (2 studies each). , Stavrakis S , Zonana-Nacach A Help us improve CareerBuilder by providing feedback about this job: Report this job Job ID: 2281236908. When expanded it provides a list of search options that will switch the search inputs to match the current selection. Gordon C , Alunno A Physician global assessments for disease activity in rheumatoid Five studies have demonstrated good ICC values for reliability (all >0.60 and ranging up to 0.97). This potentially disfiguring disease can have significant impact on patient's quality of life (QoL) and is often refractory to many first- and second-line therapies. A good responsiveness for PGA was shown in eight studies. MeSH , Petri MA , Longenecker JC CareerBuilder TIP. , Borghoff K et al. In 11 retrieved studies [10, 13, 33, 36, 45, 48, 50, 55, 56, 65, 96] the PGA was part of the SFI [104] and in 10 studies [3, 29, 40, 46, 52, 60, 69, 80, 94, 98] it was part of the SRI [3] (both discussed in the Responsiveness section). FitzGerald and Grossman [10] found a good interRR in a retrospective assessment of the PGA (=0.79). This scoring modality was used for the SRI [3]. The responsiveness of the PGA is the ability to detect worthwhile variations in disease activity over time, measuring worsening or improvements in SLE disease status. The literature search identified 91 studies. Physician global assessments for disease activity in rheumatoid arthritis are all over the map! Fatigue is independently associated with disease activity assessed using the Physician Global Assessment but not the SLEDAI in patients with systemic lupus erythematosus. et al. , Fortin PR , Sato JO The index assesses separately eight organ-based systems. Exagen Diagnostics Inc (XGN) - Product Pipeline Analysis, 2022 Update Feasibility refers not to the quality of the outcome measure, but to aspects such as completion time, cost of an instrument, equipment and type and ease of administration. Barr et al. , Navarra SV Different scores and lengths of visual evaluation were employed: the first was the 010 VAS suggested by Liang et al. Rendas-Baum R, Baranwal N, Joshi AV, Park J, Kosinski M. J Patient Rep Outcomes. SLE231 Hydrology and Water Resources Management: Excursion or Virtual Tour Navarra SV et al. 2022 Mar 14;24(1):70. doi: 10.1186/s13075-022-02756-3. , Sadovici-Bobeica V , Petri M. Iaccarino L [2, 21, 24] recommended PGA assessment prior to reviewing serological data, based only on the clinical visit. et al. All clinical diagnoses were verified by review of the patients' inpatient and outpatient files at the time of capillaroscopy. , Mohan C. Jolly M Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of multifactorial origin that can affect any organ or organ system, resulting in a broad spectrum of clinical manifestations ranging from dermatological involvement to multi-organ failure with episodes of relapses and remissions. The Patient's Global Assessment Scale (PGA) is the PRO counterpart to the Physician's Global Assessment Scale or Investigator's Global Assessment Scale (PGA-IGA). According to the OMERACT, face validity is the degree to which the instrument appears to match with the target domain, according to experts [18]. doi: 10.1136/rmdopen-2022-002395. BATCH RUBY INTENSIVE REVIEWRTRMF 3. Faculty Publications: Feb. 23-March 2 J Clin Med. , Andreoli L Patient-Reported Outcomes in Systemic Lupus Erythematosus. [8] suggested the need for a disease activity instrument that would be valid, reliable and sensitive to change. The PGA also showed good predictive validity, as it correlated significantly with measures of future outcomes, such as quality of life or laboratory exams, but no study has currently evaluated its correlation with measures of damage. Arriens C The aim of this systematic literature review (SLR) is to describe and analyse the psychometric properties of PGA. The assessment of PGA responsiveness was performed in 10 studies [4, 23, 50, 58, 7779, 81, 83, 84] using different methods [110]. Psychometric properties data were analysed according to the OMERACT Filter methodology version 2.1. , Gladman DD Clipboard, Search History, and several other advanced features are temporarily unavailable. Objective: Physician global assessments for disease activity in rheumatoid arthritis are all over the map!. et al. The Janus kinase (Jak)/signal transducer and activating protein (STAT) pathways mediate the intracellular signaling of cytokines in a wide spectrum of cellular processes. PMC The aim of this systematic literature review is to describe and analyse the psychometric properties of the PGA. 3TR (Taxonomy, Treatment, Targets and Remission) Systemic Lupus Erythematosus Study Protocol 2 , Magder LS Please check for further notifications by email. Stojan G , Garabajiu M In our centre, new tools for the assessment of SLE activity: the Lupus Activity Scoring Tool (LAST) and Clinical Lupus Activity Scoring Tool (C-LAST) were developed and validated. Patient global assessment in measuring disease activity in rheumatoid Epub 2014 Jul 10. HRQoL: Health-related Quality of Life; ICAM: intercellular adhesion molecule; VCAM: vascular cell adhesion molecule; MCP-1: monocyte chemoattractant protein-1; NC: non-calcified; suPAR: soluble urokinase plasminogen activator receptor; LFA-REAL: Lupus Foundation of America Rapid Evaluation of Activity in Lupus; CES-D: Centers for Epidemiological StudiesDepression scale; SLAQ: Systemic Lupus Erythematosus Activity Questionnaire; NA: not acquired; NS: not significant. , OMalley T In 32 studies, disease activity measured by PGA was compared with changes in laboratory markers, with the aim of correlating clinical and serological features [9, 21, 30, 32, 34, 3739, 44, 45, 48, 49, 55, 5861, 63, 64, 66, 67, 69, 71, 74, 75, 82, 86, 89, 9194]. [8] and adopted in childhood SLE; the most common tool (the 03 VAS) was developed [68] to capture the concept of flare and is measured on a 3cm VAS in the SRI [3] and a 10cm VAS in the SFI [10, 104], but other scores (02, 04, 05, 07) [11, 53, 78, 80, 86, 87] and lengths (8cm, 15cm) [10, 8284] have also been used. Franklyn K , Shea BJ Construct validity was demonstrated by a good correlation (r0.50) between the PGA with the SLEDAI (12 studies), SLAM (4 studies), LAI, BILAG and ECLAM (2 studies each). , Floris A Background: Physician Global Assessment (PGA) is a visual analogue score (VAS) that reflects the clinician's judgment of overall Systemic Lupus Erythematosus (SLE) disease activity. Reliability. 12. and later incorporated into the SLE Responder Index used in the belimumab clinical trials, 13 Montreal, Canada Area. 2022 Sep 20;19(19):11895. doi: 10.3390/ijerph191911895. They participate in physiologic and inflammatory cascades and have become a major focus of research, yielding novel therapies for immune-mediated inflammatory diseases (IMID). This may be explored through convergent and divergent validity. , Kalunian K doi: 10.1136/lupus-2022-000700. Gandhi N , Rodrigues M , Giannakou I , Francis S Content validity was reported in 89 studies. Moreover, there is uncertainty as to whether the best timing of assessment is prior to or after reviewing laboratory exams [26]. , Oon S All versions are validated and used by lupus researchers for clinical and research purposes. Exagen's products are used for therapeutic drug monitoring of hydroxychloroquine in whole blood and methotrexate polyglutamates, risk assessment testing, anti-TNF monitoring to individualize therapy and optimize dosing, and others. [9] for a disease activity index scored on a VAS ranging from 0 to 3, with an increase of 1.0 since the last visit indicating a flare. Int J Environ Res Public Health. Dynabook PX1900E-1NCA, PROTECTIVE SLE (PX1900E-1NCA) The Physician's Global Assessment (PhGA) is a number without unit. The results are similar, and less than half the time is required for scoring. In one open-label study [43], the decrease in PGA score was considered the primary endpoint. , Devilliers H . No data were found regarding the feasibility of the PGA. Objective: To examine the feasibility of using Physician Global Assessment (PGA) scores to collect and track patient acne and . Bookshelf 215 (FIVE YEARS 146) H-INDEX. ~Sle~ - . T2 - A longitudinal study. The Physician Global Assessment (PGA) is a visual analogue score that reflects the clinician's judgement of overall SLE disease activity. At least 1 issue from each virtual tour. Clinical Trial Physician - Rheumatology Job in San Diego, CA - Bristol et al. SLE2ACR1997SLICC2012. Diet and Systemic Lupus Erythematosus (SLE): From Supplementation to Intervention. Importance: In dermatology, the development of objective, standardized quality measures that can be used in a clinical setting is important to be able to respond to the needs of payers and credentialing and licensure bodies and to demonstrate dermatologic value. Epub 2014 Apr 11. Thanou A, Chakravarty E, James JA, Merrill JT. Impact of anti-SARS-CoV-2 antibodies of different isotypes (IgA, IgG, IgM) on attainment of PGA . , Hochberg M. Wallace DJ The assessment of disease activity in SLE is particularly challenging. , Lau CS Medical Cannabis Use by Rheumatology Patients Following Recreational [PDF] Use of Physician Global Assessment in systemic lupus PGA is a simple instrument and the result is easily understood. et al. A systematic review of the literature was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines [17], searching for articles reporting on the use of PGA in SLE. Uribe AG, Vil LM, McGwin G Jr, Sanchez ML, Reveille JD, Alarcn GS. RN-BSN HOLISTIC HEALTH ASSESSMENT ACROSS THE LIFESPAN (NURS 3315) Sociology of Social Problems (SOC213) However, the PGA allows for the measurement of disease activity in a global way (content validity). All rights reserved. ~SLE~. The .gov means its official. 25 (FIVE YEARS 8) Latest Documents Most Cited Documents Contributed Authors Related Sources Related Keywords Latest Documents; Most Cited Documents; Contributed Authors; Related Sources; et al. , Carpenter AB A high variability in scales was found, causing a wide range of reliability (intraclass correlation coefficient 0.67-0.98). and transmitted securely. Measurement properties of the PGA were analysed according to the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) terminology [19]. , Goldsmith CH The Physician's Global Assessment (PGA) is a pragmatic disease activity measure, using a 100 mm visual analogue scale (VAS) for physicians to quantify the patient's overall disease . It does not provide a predefined or limited list of disease manifestations or organ systems, thus allowing one to capture all the heterogeneous aspects of SLE disease activity. The SELENA-SLEDAI assesses systemic lupus erythematosus (SLE) disease activity and categorizes mild/moderate or severe flares based on changes in the SLEDAI score, the Physician's Global Assessment (PGA), medication use (prednisone, Nonsteroidal anti-inflammatory drugs, Plaquenil, major immunosuppressives), other disease activity criteria, and . Deconstruction of the safety of estrogen in lupus erythematosus national assessment-systemic lupus erythematosus disease activity index flare index, Effect of raloxifene on disease activity and vascular biomarkers in patients with systemic lupus erythematosus: subgroup analysis of a double-blind randomized controlled trial, Omega-3 in SLE: a double-blind, placebo-controlled randomized clinical trial of endothelial dysfunction and disease activity in systemic lupus erythematosus, Erythrocyte sedimentation rate is a predictor of renal and overall SLE disease activity, Characterization of clinical photosensitivity in cutaneous lupus erythematosus, Validation of the systemic lupus erythematosus responder index for use in juvenile-onset systemic lupus erythematosus, Depressive symptoms and associated factors in systemic lupus erythematosus, Validation of the Portuguese simple measure of impact of lupus erythematosus in youngsters (SMILEY) in Brazil, Anti-C1q antibodies have higher correlation with flares of lupus nephritis than other serum markers, Performance of anti-C1q, antinucleosome, and anti-dsDNA antibodies for detecting concurrent disease activity of systemic lupus erythematosus, An assessment of disease flare in patients with systemic lupus erythematosus: a comparison of BILAG 2004 and the flare version of SELENA, Noncalcified coronary plaque in systemic lupus erythematosus, Decreases in anti-double-stranded DNA levels are associated with concurrent flares in patients with systemic lupus erythematosus, Validity and reliability of lupus activity measures in the routine clinic setting, Clinical predictors of response and discontinuation of belimumab in patients with systemic lupus erythematosus in real life setting. , Burlingame RW Visual analogue scales (VAS) allow rapid, continuous scaling of disease severity. In the last 30years, more than a dozen scores have been derived to assess disease activity in SLE, but not all of these have proven to be valid and reliable tools. , Hambleton IR Objective: The Physician Global Assessment (PGA) is a visual analogue score that reflects the clinician's judgement of overall SLE disease activity. , Nguyen SC The aim of this systematic review is to describe and analyse the measurement properties of the PGA, including the validity, reliability, responsiveness and feasibility. In 1988, Liang et al. The correlation with the SLEDAI was determined in 12 studies (Fig. , Ogale S 2019ACREULAR . Patient-reported outcomes (PROs) reflect the patient's perspective and are used in rheumatoid arthritis (RA) routine clinical practice. , Landis RC SLE is an immune-mediated multisystemic disease characterized by a wide variability of clinical manifestations and a course frequently subject to unpredictable flares [1, 2]. , Hennis A. Jesus D These results enabled its use as a gold standard for assessing flare and defining flare severity in several studies [21, 67, 88]. Physician's Global Assessment Scale (PGA) or Investigator's Global Assessment Scale (IGA) measures disease status in a broad range of diseases. A multi-item Physician Global Assessment scale to assess psoriasis Barr SG The 4-point PGA (0, no flare; 1, mild; 2, moderate; 3, severe) showed the lowest IRR in assessing flare (ICC=0.18) compared with the BILAG-2004 (ICC=0.54) and SFI (ICC=0.21) [65]. , Pego-Reigosa J-M , Ibaez D , Magder LS The literature search identified 91 studies. Use of Physician Global Assessment in systemic lupus erythematosus: a et al. et al. Federal government websites often end in .gov or .mil. Methods: This systematic literature review was conducted by two independent reviewers in accordance with the Preferred Reporting Items . Touma Z , Gayet-Ageron A This button displays the currently selected search type. Eudy AM physician's global assessment (PGA) of disease activity in SLE. RMD Open 2018;4:e000578. The Author(s) 2020. independently selected the articles, initially on the basis of titles and abstracts, then, if necessary, on the full texts, an eligibility assessment was performed independently in a blinded standardized manner. The aim of this systematic literature review is to describe and analyse the psychometric properties of the PGA. Forbess LJ , Arora S Psychometric properties data were analysed according to the OMERACT Filter methodology version 2.1. disease activity). The Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus (PISCOS) study aimed to obtain an evidence-based and expert-based consensus standardisation of the Physician Global Assessment (PGA) scoring of disease activity in systemic lupus erythematosus (SLE). Use of Physician Global Assessment in systemic lupus - PubMed
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